In this study we evaluated the short-term oral antihypertensive effect gul rune d2 of several peptide sequences isolated from cuttlefish (Sepia officinalis) muscle proteins hydrolysates, previously characterized as in vitro angiotensin-I-converting enzyme-inhibitors, in spontaneously hypertensive rats (SHR).Systolic blood pressure (SBP) and the diastolic blood pressure (DBP) of the rats were measured by the tail cuff method before administration and also 2, 4, 6, 8 and 24 h post-administration.The peptide sequences Val-Tyr-Ala-Pro, Val-Ile-Ile-Phe and Ala-His-Ser-Tyr showed a clear decrease in SBP and DBP in SHR.Met-Ala-Trp caused a significant decrease of the SBP in the SHR, but this sequence caused gemplers free shipping a slight decrease in DBP in these animals.
SBP and DBP returned to baseline values 24 h post-administration of all peptides.Thus, these peptides are bioactive ingredients with potential benefit in the prevention and treatment of hypertension.